2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140212
    Azido-PEG1-amine 464190-91-8 ≥98.0%
    Azido-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azido-PEG1-amine
  • HY-130907
    Fmoc-N-PEG24-acid 2170484-59-8 99.91%
    Fmoc-N-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-PEG24-acid
  • HY-W045598
    Boc-C16-COOH 843666-40-0 99.91%
    Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    Boc-C16-COOH
  • HY-138461
    Azido-PEG1 1517-05-1 99.95%
    Azido-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azido-PEG1
  • HY-130653
    Azido-PEG4-C2-acid 1257063-35-6 ≥98.0%
    Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azido-PEG4-C2-acid
  • HY-140459
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid 846549-37-9 ≥98.0%
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
  • HY-108368
    Azido-PEG2-CH2COOH 882518-90-3 99.03%
    Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azido-PEG2-CH2COOH
  • HY-140921
    Biotin-PEG4-amino-t-Bu-DADPS-C6-azide 1260247-50-4
    Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Biotin-PEG4-amino-t-Bu-DADPS-C6-azide
  • HY-140452
    Azido-PEG2-C2-acid 1312309-63-9
    Azido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azido-PEG2-C2-acid
  • HY-141167
    TCO-PEG4-NHS ester 1613439-69-2 99.58%
    TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    TCO-PEG4-NHS ester
  • HY-W046471
    N-Boc-PEG4-bromide 1076199-21-7 ≥98.0%
    N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG4-bromide
  • HY-113697
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD 1037589-69-7 99.77%
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (Mal-PEG2-AZD) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
  • HY-69220
    7-Octynoic acid 10297-09-3 ≥98.0%
    7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    7-Octynoic acid
  • HY-141106
    m-PEG12-NHS ester 2207596-93-6 ≥98.0%
    m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-NHS ester
  • HY-W015088
    Amino-PEG3-C2-Amine 929-75-9 99.32%
    Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG3-C2-Amine
  • HY-135804
    NH2-PEG3-C2-Boc 252881-74-6
    NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG3-C2-Boc
  • HY-W010975
    Fmoc-Lys-OH hydrochloride 139262-23-0 99.48%
    Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-Lys-OH hydrochloride
  • HY-22340
    Azido-PEG4-alcohol 86770-67-4 ≥98.0%
    Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG4-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Azido-PEG4-alcohol
  • HY-W008352
    Boc-NH-PEG4-CH2CH2NH2 811442-84-9 ≥98.0%
    Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG4-CH2CH2NH2
  • HY-W006524
    H2N-PEG2-CH2COOH 134978-97-5 99.87%
    H2N-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    H2N-PEG2-CH2COOH
PROTAC Linkers Isoform Comparison

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